Journal article
Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection
DS Khoury, TE Schlub, D Cromer, M Steain, Y Fong, PB Gilbert, K Subbarao, JA Triccas, SJ Kent, MP Davenport
Emerging Infectious Diseases | Published : 2023
Abstract
Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these studies vary in terms of estimates of the level of neutralizing antibodies required for protection. By normalizing antibody titers, we found that study results converge on a consistent relationship between antibody levels and protection from COVID-19. This finding can be useful for planning future vaccine use, determining population immunity, and reducing the global effects of the COVID-19 pandemic.
Grants
Awarded by Department of Health and Aged Care, Australian Government
Funding Acknowledgements
We thank Moriah Bergwerk, Tal Gonen, Gili Regev-Yoshay, and colleagues for supplying the raw data from their study of neutralization titers in BNT162b2-vaccinated healthcare workers (5) . This work is supported by Australian government Medi-cal Research Future Fund awards GNT2002073 (M.P.D. and S.J.K.) , MRF2005544 (S.J.K. and M.P.D.) , MRF2005760 (M.P.D.) , and MRF2007221 (J.A.T. and M.S.) ; a National Health and Medical Research Council (NHMRC) program grant GNT1149990 (S.J.K. and M.P.D.) ; and the Victorian Government (S.J.K.) . D.S.K. and S.J.K. are supported by NHMRC fellowships. D.C. and M.P.D. are supported by NHMRC Investigator grants. The Melbourne WHO Collabo-rating Centre for Reference and Research on Influenza is sup-ported by the Australian Government Department of Health. The funding sources had no role in the writing of the manuscript or the decision to submit it for publication or in data collection, analysis, or interpretation or in any aspect pertinent to the study. Authors were not precluded from accessing data in the study, and they accept responsi-bility to submit for publication